Record Display for the EPA National Library Catalog

RECORD NUMBER: 535 OF 1113

Main Title Multicompartment Kinetic Models for Lead. 2. Linear Kinetics and Variable Absorption in Humans without Excessive Lead Exposures.
Author Marcus, A. H. ;
CORP Author Washington State Univ., Pullman. Dept. of Pure and Applied Mathematics.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/J-85/425;
Stock Number PB86-220381
Additional Subjects Lead(Metal) ; Toxicology ; Metabolism ; Diet ; Models ; Reprints ; Multicompartment models
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB86-220381 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Abstract
Multicompartment models with constant fractional transfer rates have been fitted to experimental data on lead metabolism in four subjects studied by M. B. Rabinowitz, G. W. Wetherill, and J. D. Kopple (Science 182, 725-727, 1973; Environ. Health Perspect. 7, 145-153, 1974; Arch. Environ. Health 31, 220-223, 1976; J. Clin. Invest. 58, 260-270, 1976; J. Lab Clin. Med. 90, 238-248, 1977). Long-term retention is estimated for blood, soft tissue, cortical and trabecular bone pools, and for facial hair. The absorption of lead from diet is shown to change with time, but no evidence was found for other variable or nonlinear kinetic mechanisms of lead metabolism in humans without excessive lead exposure.