Record Display for the EPA National Library Catalog


Main Title Conditioned Flavor Aversions: Applications in Assessing the Efficacy of Chelators in the Treatment of Heavy-Metal Intoxication.
Author Peele, D. B. ; Farmer, J. D. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1987
Report Number EPA/600/J-87/120;
Stock Number PB88-144357
Additional Subjects Chelating agents ; Nervous system ; Toxic diseases ; Lead poisoning ; Toxicology ; Thallium ; Rats ; Laboratory animals ; Reprints ; Flavor aversions ; Heavy metals ; Intoxication ; Dimercaprol ; Food preferences
Library Call Number Additional Info Location Last
NTIS  PB88-144357 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
A series of studies investigated the conditioned flavor aversions induced by administration of either lead or thallium in combination with either dimercaprol or dimercaptosuccinic acid in an attempt to correlate changes in flavor-aversion conditioning to changes known to alter the toxicity of metal administration. Rats receiving either lead or thallium showed significant reductions in saccharin preferences (i.e., conditioned flavor aversions). Rats receiving lead acetate in combination with either of the two chelators displayed significantly reduced conditioned flavor aversions when compared to the aversions induced in rats receiving lead alone. Under the same conditions, there were no differences in the conditioned flavor aversions of rats receiving thallium only and those of rats receiving thallium in combination with either of the two chelators. Attenuation of the lead-induced conditioned flavor aversions was eliminated when chelator administration was delayed by 4 hr. This attenuation of lead-induced but not thallium-induced aversions by dimercaprol and dimercaptosuccinic acid demonstrates the sensitivity and selectivity of the flavor-aversion conditioning paradigm in characterizing metal-chelator interactions.