Record Display for the EPA National Library Catalog


Main Title 1,2-butylene Oxide: Skin Sensitization Potential in the Guinea Pig with Cover Letter from Bowman Cm, 2020 dow Center to Timm G, Ots dated 01/23/1984.
CORP Author Dow Chemical Co., Midland, MI. Toxicology Research Lab.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1984
Report Number 40-8475031
Stock Number OTS0507304
Additional Subjects Toxicology ; Health effects ; Butylene Oxide ; Primary Dermal Sensitization ; Mammals ; Guinea Pigs ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 106-88-7
Library Call Number Additional Info Location Last
NTIS  OTS0507304 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 8p
Skin sensitization potential of 1,2- butylene oxide was evaluated in 10 male Hartley albino guinea pigs exposed to 0.1 ml of undiluted test compound 4 times over a 7 day period, followed 2 weeks later by a single challenge exposure. Treatment did not produce signs of sensitization in any of the guinea pigs, whereas 9 of 10 guinea pigs exposed to a positive control solution (0.1 ml of DER 331) exhibited a positive response indicative of sensitization. The authors concluded that the test compound was not a potential human skin sensitizer.