Record Display for the EPA National Library CatalogRECORD NUMBER: 39 OF 4460
|Main Title||79-week Progress Report: an 18-month Vapor Inhalation Safety Evaluation Study in Hamsters with Attachments and Cover Sheet Dated 07/17/1989 (Sanitized).|
|CORP Author||Hazleton Labs., Falls Church, VA.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Health effects ; Methyl Methacrylate (80-62-6) ; Chronic Toxicity ; Mammals ; Hamsters ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 80-62-6|
Chronic toxicity was evaluated in hamsters (53-59/sex/dose group) exposed to methyl methacrylate vapor at concentrations of 0, 25, 100, or 400 ppm for 6 hours/day, 5 days/week for 18 months. Mortality rates, in the control, low-, mid-, and high-dose groups were 34.5, 43.4, 35.7, and 60.0% (males) and 72.7, 64.9, 62.5 and 68.8% (females), respectively. Treatment did not affect body weight gain, hematocrit level, or erythrocyte and leukocyte counts. Hemoglobin concentration was decreased in high-dose males sampled at 79 weeks, but was normal in all other groups. Numerous gross abnormalities were seen in control and treated rats, but no statistical analysis of these results was reported.