Novartis submitted three previous (8e) notices for this same chemical substance. The first, on October 24, 1997 reported effects from a rat oral teratogenicity study. The second, on December 10, 1997, reported effects from a subchronic oral toxicity study in rats. The third on December 30, 1998, reported effects from a subchronic oral toxicity in beagle dogs. In accordance with EPA's March 16, 1978 policy statement on Section 8(e) reporting under the Toxic Substances Control Act and EPA's June 1991 TSCA Section 8(e) Reporting Guide, Novartis wishes to bring to your attention certain preliminary findings from an 18-month mouse oncogenicity study (Study No. 971013) conducted in the laboratories of Novartis in Stein, near Basle, Switzerland, with the chemical substance.