Record Display for the EPA National Library Catalog


Main Title Initial Submission: TSCA Health and Safety Study Cover Sheet with Continuation Sheet Summarizing Pilot Study on Developmental Toxicity in Rats after Oral Administration of PLT 2930, dated 10/05/99.
CORP Author Bayer A.G., Wuppertal (Germany, F.R.).;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 12 Oct 1999
Year Published 1999
Report Number 8EHQ-1099-14564;
Stock Number OTS-0559811
Additional Subjects Toxicity ; Rats ; Laboratory animals ; Fetuses ; Gavage ; Dosage ; Females ; Mortality ; PLT 2930
Library Call Number Additional Info Location Last
NTIS  OTS-0559811 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 6p
Ten mated female Wistar rats each were daily treated orally by gavage with PLT 2930 in 0.5 % carboxymethylcellulose in demineralized water from day 6 to day 19 p.c. in doses of 0, 10 and 1000 mg/kg body weight (b.w.)/day. Due to an incidentally low fertility rate 6 further mated females were added to the 10 mg/kg group. The fetuses were delivered by cesarean section on day 20 p.c. and blood was taken of the females by cardiac puncture together with maternal fatty tissue (renal fat) as well as one fetus each of the first 5 litters per group for toxicokinetic investigations (will be reported separately). Investigations were performed on general tolerance of the test compound by the females as well as on its effect on intrauterine development with external and skeletal evaluation of fetuses. Additionally macroscopically altered fetal adrenal glands were evaluated histopathologically.