Record Display for the EPA National Library Catalog


Main Title Study Report on Inhalation Median Lethal Concentration (LC50) with Cover Letter and EPA Responses dated 03/26/83.
CORP Author Du Pont de Nemours (E.I.) and Co., Wilmington, DE.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 25 Nov 1981
Year Published 1981
Report Number FYI-OTS-1183-0266-SU;
Stock Number OTS-0000266-1
Additional Subjects Rats ; Inhalation ; Vapors ; Aerosols ; LC50 ; O-toluidine ; Lethal concentrations ; Head only exposure
Library Call Number Additional Info Location Last
NTIS  OTS-0000266-1 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 26p
Groups of 8-week old Crl: CD (tradename) male rats were exposed, head-only, to atmospheres of o-toluidine for single 4-hours periods. The LC50(sup double star) was determined to be 862 ppm with 95% confidence limits between 816 and 913 ppm. Compound-related clinical signs observed during and immediately following exposure consisted of tremors, slight to moderate cyanosis, muscle spasms, labored breathing, slight to moderate corneal opacity, prostration and semi-prostration, and reddish-brown nasal discharge. Clinical signs observed at 24 hours or longer consisted of corneal opacity, prostration, lethargy, labored breathing, pallor, hypothermia, reddish-brown nasal discharge, and stained-wet perinea. Weight losses of 6 to 22% were observed 1 to 3 days post-exposure, with normal weight gains occurring thereafter. The clinical manifestations of o-toluidine were generally dose-related. Deaths occurred with 1 to 4 days post-exposure. Time to death generally decreased as exposure concentrations increased.