Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 10

Main Title Letter Submitting One Enclosed Teratology Study and One Enclosed Supplementary Study on Isopropanol.
CORP Author British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 86-920000727
Stock Number OTS0535606
Additional Subjects Toxicology ; Health effects ; Isopropanol (67-63-0) ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 67-63-0
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  OTS0535606 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 183p
Abstract
Isopropanol (CAS No. 67-63-0) was tested for developmental toxicity. The test substance was administered orally in the drinking water at 0, 0.5, 1.25, and 2.5% to pregnant rats (20/group) on gestation days 6-16. The rats were sacrificed on day 20 for examination. Animals in the two highest dose groups had reduced food and water intake, and a decrease in body weight was noted in the 2.5% group. Mean litter weight decreased with increasing concentration, and there was a statistically significant decrease in mean fetal body weight in the two highest groups compared to controls. No evidence of teratogenicity was noted.