Record Display for the EPA National Library Catalog


Main Title Chloroform-Induced Multiple Forms of Ornithine Decarboxylase: Differential Sensitivity of Forms to Enhancement by Diethyl Maleate and Inhibition by ODC-Antizyme.
Author Savage, R. E. ; Nofzinger, K. ; Bedell, C. ; DeAngelo, A. B. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/057;
Stock Number PB90-103474
Additional Subjects Chloroform ; Toxicology ; Liver ; Rats ; Reprints ; Ornithine decarboxylase ; Isoenzymes ; Enzyme induction ; Diethyl maleate ; Gel chromatography
Library Call Number Additional Info Location Last
NTIS  PB90-103474 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
It has been reported that chloroform induces rat liver ornithine decarboxylase (ODC). In both male and female rat liver this induction is dose-dependent and maximal 18 hours after a single intraperitoneal dose. Two distinct forms of the enzyme are induced in rat liver. Pretreatment of animals with diethyl maleate enhances the effect of chloroform. In addition, chloroform induces hepatic ornithine decarboxylase-antizyme (ODC-AZ) in rat liver. The study reports on the effect of diethyl maleate pretreatment on the chloroform induction of two different forms of male rat liver ODC and the sensitivity of the two forms of the enzyme to inhibition by ODC-AZ.