Record Display for the EPA National Library CatalogRECORD NUMBER: 34 OF 34
|Main Title||Will the Mouse Bioassay for Estimating Sensory Irritancy of Airborne Chemicals (ASTM E 981-84) Be Useful for Evaluation of Indoor Air Contaminants.|
|Author||Tepper, J. S. ; Costa, D. L. ;|
|CORP Author||ManTech Environmental Technology, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.|
|Report Number||EPA-68-D2-0056; EPA/600/J-94/331;|
|Additional Subjects||Indoor air pollution ; Irritants ; Test methods ; Bioassay ; Mice ; Exposure ; Risk assessment ; Laboratory tests ; Air pollution detection ; Air pollution effects(Humans) ; Reprints ; American Standard Test Method E 981-84 ; ASTM E 981-84|
For many toxic inhalants, sensory irritation is the first detectable response. A standardization bioassay, ASTM E 981-84, that quantitates irritancy as a reduction in breathing rate of the mouse during inhalation exposure, has been developed. The validation of this screen for detecting irritation is based on the high rank-correlation between 0.03 x RD(50) and the TLVs-TWAs for numerous inhaled chemicals. The screen does not indicate the relative offensiveness of an odor, does not address all pulmonary hazards or non-irritating systemic hazards, and is not a replacement for chronic toxicity testing. Despite the limitations, prudent application of ASTM E 981-84 appears to provide a rapid, inexpensive means to identify indoor atmospheres of irritant potential.