Record Display for the EPA National Library Catalog
RECORD NUMBER: 17 OF 25| Main Title | Metabolism of 2-chloro'u-ring-14c/toluene by Rats Dosed Intravenously. | |||||||||||
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| CORP Author | Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 2000 | |||||||||||
| Report Number | 40-8335096 | |||||||||||
| Stock Number | OTS0507459 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; 2-chlorotoluene ; Pharmaco Kinetics ; Mammals ; Rats ; Parenteral ; Intravenous ; Toxic substances ; Laboratory animals ; CAS No 95-49-8 | |||||||||||
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| Collation | 15p | |||||||||||
| Abstract | The metabolism of 2-chlorotoluene was examined in 4 female rats (strain not reported) injected intravenously with a single 0.7 mg/kg dose of (U-ring-14C)2-chlorotoluene. Rats eliminated 69-81% and 14-18% of the applied dose in the urine and as expired volatiles, respectively, within 4 days after dosing. Nearly all of the volatile 14C in expired air was 2-chlorotoluene. The primary urinary metabolites were mercapturic acid, glucuronide, and 2- chlorohippurate, representing 22-24, 13-20, and 7-11% of urinary 14C, respectively. |