Record Display for the EPA National Library Catalog


Main Title 7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction.
Author House, R. V. ; Pallardy, M. J. ; Burleson, G. R. ; Dean, J. H. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Sterling Research Group, Rensselaer, NY. Dept. of Toxicology.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/482;
Stock Number PB90-185273
Additional Subjects Lymphocytes ; Cytology ; Antigen antibody reactions ; Reprints ; Dimethylbenz(a)anthracene ; Cytokines ; Cytotoxic T lymphocytes ; Interferon type I ; Dose-response relationships ; Interferon type II ; Macrophage activation
Library Call Number Additional Info Location Last
NTIS  PB90-185273 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Murine lymphocytes were exposed to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and several cytokines were measured. Production of interleukin-1 by macrophages, interleukin-2 by EL-4 thymoma, and gamma interferon by activated splenic lymphocytes were not affected by DMBA. However, interleukin-5 (also known as T cell replacing factor) was significantly suppressed by DMBA. Cloned cytotoxic T lymphocyte activity was inhibited in a dose-dependent manner by DMBA and the suppression was significantly enhanced by addition of beta or gamma interferon. The results support the hypothesis that, rather than acting as a non-specific inhibitor of lymphocyte proliferation, DMBA-induced suppression of antigen-specific cytolysis is a mechanism directed against highly-specific cellular targets in the immune process.