| Main Title |
7,12-Dimethylbenz(a)anthracene-Induced Modulation of Cytokines Involved in Cytotoxic T Lymphocyte Induction. |
| Author |
House, R. V. ;
Pallardy, M. J. ;
Burleson, G. R. ;
Dean, J. H. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC. ;Sterling Research Group, Rensselaer, NY. Dept. of Toxicology. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/482; |
| Stock Number |
PB90-185273 |
| Additional Subjects |
Lymphocytes ;
Cytology ;
Antigen antibody reactions ;
Reprints ;
Dimethylbenz(a)anthracene ;
Cytokines ;
Cytotoxic T lymphocytes ;
Interferon type I ;
Dose-response relationships ;
Interferon type II ;
Macrophage activation
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-185273 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Murine lymphocytes were exposed to the carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) and several cytokines were measured. Production of interleukin-1 by macrophages, interleukin-2 by EL-4 thymoma, and gamma interferon by activated splenic lymphocytes were not affected by DMBA. However, interleukin-5 (also known as T cell replacing factor) was significantly suppressed by DMBA. Cloned cytotoxic T lymphocyte activity was inhibited in a dose-dependent manner by DMBA and the suppression was significantly enhanced by addition of beta or gamma interferon. The results support the hypothesis that, rather than acting as a non-specific inhibitor of lymphocyte proliferation, DMBA-induced suppression of antigen-specific cytolysis is a mechanism directed against highly-specific cellular targets in the immune process. |
