Record Display for the EPA National Library Catalog


Main Title EPA's reanalysis of key issues related to dioxin toxicity and response to NAS comments. in support of summary information on the integrated risk information system (IRIS). Volume 1 :
CORP Author Environmental Protection Agency, Washington, DC. National Center for Environmental Assessment.
Publisher U.S. Environmental Protection Agency,
Year Published 2012
Report Number EPA/600/R-10/038F
Stock Number PB2012-108154
Subjects Dioxins--Toxicology ; Health risk assessment
Additional Subjects Toxicity ; Dioxins ; US EPA ; Polychlorinated biphenyls ; Hydrocarbons ; Hazardous materials ; Solid wastes ; Chemical mixtures ; Fires ; Food ; Animals ; Pollution sources ; Environmental exposure pathway ; Health effects ; Dose response relationships ; Integrated Risk Information System(IRIS)
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB2012-108154 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 2 online resource ([1865] pages) : digital, PDF file
Dioxins and dioxin-like compounds (DLCs), including polychlorinated dibenzo-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls, are structurally and toxicologically related halogenated dicyclic aromatic hydrocarbons. Dioxins and DLCs are released into the environment from several industrial sources such as chemical manufacturing, combustion, and metal processing; from individual activities including the burning of household waste; and from natural processes such as forest fires. Dioxins and DLCs are widely distributed throughout the environment and typically occur as chemical mixtures. They do not readily degrade; therefore, levels persist in the environment, build up in the food chain, and accumulate in the tissues of animals. Human exposure to these compounds occurs primarily through the ingestion of contaminated foods (Lorber et al., 2009), although exposures to other environmental media and by other routes and pathways do occur. The health effects from exposures to dioxins and DLCs have been documented extensively in epidemiologic and toxicological studies. 2,3,7,8-Tetrachlor odibenzo-p-dioxin (TCDD) is one of the most toxic members of this class of compounds and has a robust toxicological database. Characterization of TCDD toxicity is critical to the risk assessment of mixtures of dioxins and DLCs because it has been selected repeatedly as the 'index chemical' for the dioxin toxicity equivalence factors (TEF) approach.
"February 2012." "CAS no. 1746-01-6." "EPA/600/R-10/038F." Title from title screen (viewed on 5/8/12). Includes bibliographical references.