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Main Title Toxicological Review of Trichloroethylene (CAS No. 79-01-6) in Support of Summary Information on the Integrated Risk Information System (IRIS). Appendices.
CORP Author Environmental Protection Agency, Washington, DC.
Year Published 2011
Report Number EPA/534/R-011F-APP
Stock Number PB2012-100126
Additional Subjects Trichloroethylene ; Toxicological review ; Toxicity ; Health effects ; Exposure characterization ; Toxicokinetics ; Hazard characterization ; Epidemiologic studies ; Laboratory studies ; Genetic toxicity ; Tables(Data) ; Absorption metabolism ; Environmental fate ; Exposure concentrations ; Integrated Risk Information System(IRIS) ; Physiologically Based Pharmacokinetic(PBPK) ; TCE(Trichloroethylene)
Library Call Number Additional Info Location Last
NTIS  PB2012-100126 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1269p
There is substantial potential for human exposure to trichloroethylene (TCE), as it has a widespread presence in ambient air, indoor air, soil, and groundwater. At the same time, humans are likely to be exposed to a variety of compounds that are either metabolites of TCE or which have common metabolites or targets of toxicity. Once exposed, humans, as well as laboratory animal species, rapidly absorb TCE, which is then distributed to tissues via systemic circulation, extensively metabolized, and then excreted primarily in breath as unchanged TCE or carbon dioxide, or in urine as metabolites. The purpose of this Toxicological Review is to provide scientific support and rationale for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to trichloroethylene. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of trichloroethylene.