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Main Title Toxicological Review of cis-1,2-Dichloroethylene and trans-1,2-Dichloroethylene (CAS Nos. cis: 156-592-2: trans- 156-60-5: mixture: 540-59-0). In Support of Summary Information on the Integrated Risk Information System (IRIS).
Author A. Glizia ; C. Thompson ; T. Berner ; C. Cai ; S. Rieth
CORP Author Environmental Protection Agency, Washington, DC.
Year Published 2010
Report Number EPA/635/R-09/006F
Stock Number PB2011-106124
Additional Subjects Toxicity ; Dichlorethylene ; Environmental exposure ; Risk assessment ; Health hazards ; Dose-response relationships ; Carcinogenicity ; Health effects ; Oral dosage ; Human population ; Inhalation ; Respiratory system ; CAS Nos 156-592-2 ; Integrated Risk Information System(IRIS)
Library Call Number Additional Info Location Last
NTIS  PB2011-106124 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 174p
This document presents background information and justification for the Integrated Risk Information System (IRIS) Summaries of the hazard and dose-response assessments of cis- and trans-1,2-dichloroethylene (cis- and trans-1,2-DCE). Toxicological assessment of mixtures of cis- and trans-1,2-DCE is beyond the scope of this document. IRIS Summaries may include oral reference dose (RfD) and inhalation reference concentration (RfC) values for chronic and other exposure durations, and a carcinogenicity assessment. The RfD and RfC, if derived, provide quantitative information for use in risk assessments for health effects known or assumed to be produced through a nonlinear (presumed threshold) mode of action. The RfD (expressed in units of mg/kg-day) is defined as an estimate (with uncertainty spanning perhaps an order of magnitude) of a daily exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. The inhalation RfC (expressed in units of mg/m3) is analogous to the oral RfD, but provides a continuous inhalation exposure estimate. The inhalation RfC considers toxic effects for both the respiratory system (portal-of-entry) and for effects peripheral to the respiratory system (extrarespiratory or systemic effects). Reference values are generally derived for chronic exposures (up to a lifetime), but may also be derived for acute (.24 hours), short-term (>24 hours up to 30 days), and subchronic (>30 days up to 10 percent of lifetime) exposure durations, all of which are derived based on an assumption of continuous exposure throughout the duration specified.