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Main Title Zinc Metabolism and the Activity of Alkaline Phosphatase in the Kidneys of White Rats in Alloxan Diabetes and in Repeated Administration of Insulin (Obmen Tsinka i Aktivnost Shchelochnoi Fosfatazy v Pochkakh Belykh pri Alloksanovom Diabete i Povtornykh Vvedeniyakh Insulina).
Author Shevchuk., I. A. ;
CORP Author Environmental Protection Agency, Research Triangle Park, N.C. Translation Services Section.
Year Published 1973
Report Number EPA-TR-74-123;
Stock Number PB-258 752-T
Additional Subjects Diabetes ; Metabolic diseases ; Zinc ; Phosphatases ; Kidney ; Insulin ; Metabolism ; Endocrinology ; Histology ; Cytology ; Physiology ; Experimental data ; Laboratory animals ; Rats ; USSR ; Translations ; Histocytochemistry
Library Call Number Additional Info Location Last
NTIS  PB-258 752-T Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Experiments were performed on white rats with alloxan diabetes and following repeated insulin injections. Zinc distribution was studied histochemically, and the activity of alkaline phosphatase was studied by Gomori's method in the renal tubular cells. Zinc was distributed irregularly in the kidney: its highest concentration was found in the cells of the juxta-glomerular apparatus, in the margin of the cells in the main division of the nephron, in the ascending portion of Henle's loop, and in the tubules of the insertion portion. The highest alkaline phosphatase activity was found in the cells of the main division of the nephron. In alloxan diabetes, the zinc content and the alkaline phosphatase activity showed a sharp decrease, while in the case of repeated insulin injections these indices were observed to rise. A correlation was found between the alkaline phosphatase activity and zinc content in nephron tubules.