Record Display for the EPA National Library CatalogRECORD NUMBER: 7 OF 9
|Main Title||Metabolism of carbamate insecticides /|
|Author||Dorough, H. Wyman.|
|CORP Author||Kentucky Univ., Lexington. Dept. of Entomology.|
|Publisher||National Technical Information Service : Environmental Protection Agency, Technical Publications Branch, Ofice of Administration,|
|Report Number||EPA-650/1-74-002; EPA-R-802005|
|Stock Number||PB-231 596|
|Subjects||Insecticides--Research ; Aldicarb--Research ; Carbaryl--Research ; Carbofuran--Research|
|Additional Subjects||Carbamates ; Insecticides ; Biochemistry ; Metabolism ; Insects ; Mammals ; Plants(Botany) ; Residues ; Livestock ; Poultry ; Public health ; Bioassay ; Rats ; In vitro analysis ; Catabolism ; Temiks ; Carbaryl ; Carbofuran|
|Collation||x, 244 pages : charts ; 27 cm.|
The metabolic fate of aldicarb, carbaryl, and carbofuran was investigated in a variety of biological systems. In addition, the effects of other insecticides and certain monoamine oxidase inhibitors on carbaryl metabolism in rats was studied. The fate of 3-hydroxy carbofuran, its glucoside and glucuronide, and naphthyl glucoside in rats was determined. Using 1-naphthol as a model compound, in vitro methods were developed to study mechanisms of glycosylation in insects and mammals. The glucosides of 4- and 5-hydroxy carbaryl were prepared chemically and their acute toxicity to mice compared to the aglycones. Results of these studies showed that carbamate insecticides are metabolized initially by hydrolytic- and oxidative-type reactions and the resulting products are then almost totally conjugated. These conjugated products constitute the majority of the terminal residues of carbamates in both animals and plants.
EPA-650/1-74-002. Includes bibliographical references (pages 226-233).
The metabolism of selectd carbamate insecticides and certain of their key metabolites are reported. Aldicarb was studied in lactating cows, laying hens, and in boll weevils and houseflies. Carbaryl was investigated in lactating cows and in soil. Carbofuran was studied in houseflies. Effects of exposure to mixtures of pesticides on the metabolism of carbaryl were determined. The fate of the carbaryl was compared to that in animals exposed to carbaryl alone. Similar studies were conducted where monoamine oxidase inhibitors were given to the rats. Aldicarb, an oxime carbamate, was evaluated for its effect on the toxicity of methyl parathion to rats. Radioactive 3-hydroxycarbofuran was biosynthesized and its metabolism investigated in rats and bean plants. Similar studies were performed with its glucoside and glucuronide and with 1-naphthol and its glucoside conjugate. Mechanisms of glycosylation were studied in a variety of animal species. Successful chemical systheses of the glucosides of 1-naphthol, 4-hydroxycarbaryl and 5-hydroxycarbaryl were accomplished. Acute toxicity of the carbamate derivatives to rats was determined.