| Main Title |
Subchronic Toxicity of Para-Cresol in Sprague Dawley Rats: MBA Chemical No. 25. |
| Author |
Dietz, D. ;
Mulligan, L. T. ;
|
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC. ;Microbiological Associates, Bethesda, MD.;Environmental Protection Agency, Washington, DC. Office of Solid Waste. |
| Year Published |
1988 |
| Report Number |
EPA-68-01-7075; EPA/530/SW-88/025; |
| Stock Number |
PB88-195292 |
| Additional Subjects |
Toxicology ;
Dosage ;
Ingestion(Biology) ;
Bioassay ;
Laboratory animals ;
Pathology ;
Mortality ;
Para cresol ;
CAS 106-44-5 ;
4-cresol
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-195292 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
378p |
| Abstract |
The study examined the oral toxicity of para-cresol (p-cresol) in Sprague Dawley rats during 13 weeks of oral gavage administration. Dose levels studied were 0, 50, 175 and 600 mg/kg/day. Three females treated with the high dose of p-Cresol died during the first three days of the study. Signs of central nervous system (CNS) depression were apparent in high-dose males and females. Reductions in body weight gain were seen for males and females treated at the high dose level and to a lesser extent in the mid dose males. Para-cresol was hepatotoxic, nephrotoxic, and induced a mild anemic state. Based on the results of the present investigation, 50 mg/kg/day appears to be the level at which no toxic effects were observed under the conditions of the present study. |
