Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Chemical Characterization and Disposition Studies with 1,2,7,8-Tetrabromodibenzofuran in the Rat.
Author Kedderis, L. B. ; Jackson, J. A. ; Patterson, D. G. ; Grainger, J. ; Diliberto, J. J. ;
CORP Author North Carolina Univ. at Chapel Hill. Curriculum in Toxicology. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. ;Centers for Disease Control and Prevention, Atlanta, GA. Div. of Environmental Health Lab. Sciences.;Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div.
Publisher cJan 94
Year Published 1994
Report Number EPA-R817643; EPA/600/J-94/317;
Stock Number PB94-197191
Additional Subjects Toxicology ; Pharmacokinetics ; Nuclear magnetic resonance ; Rats ; Pollutants ; High pressure liquid chromatography ; Mass fragmentography ; Infrared spectroscopy ; Bile ; Skin(Anatomy) ; Absorption ; Reprints ; Tetrabromodibenzofurans
Library Call Number Additional Info Location Last
NTIS  PB94-197191 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/11/1994
Collation 19p
The present studies were designed to characterize the chemical disposition of a tetrabrominated dibenzofuran. The isomer-specific pattern of 1,2,7,8-tetrabromodibenzofuran (TBDF) was chemically characterized using high-pressure liquid chromatography, gas chromatography/mass spectrometry, infrared absorption, and proton nuclear magnetic resonance techniques. The absorption, distribution, and elimination of 1,2,7,8-(4,6-(3)H)-TBDF were examined in the rat following a single oral, dermal, or intravenous dose of 1 nmol/kg. The decline in hepatic concentrations observed in the iv and bile studies occurred in conjunction with metabolic elimination as well as a slight accumulation in adipose tissue. Dermal absorption of 1,2,7,8-TBDF, quantified as the amount contained in tissues (excluding the skin site) and excreta at 72h, was estimated to be 29% of the administered dose. Thus, the general disposition profile of 1,2,7,8-TBDF in the rat is similar to that of other polyhalogenated aromatic hydrocarbons. Due to its rapid elimination, which is consistent with its predicted susceptibility to metabolic elimination, acute exposure to 1,2,7,8-TBDF would not be expected to result in the degree of toxicity associated with other more persistent congeners.