||Developing Improved Strategies to Determine Male Reproductive Risk from Environmental Toxins.
Berndtson, W. E. ;
Clegg, E. D. ;
||Environmental Protection Agency, Washington, DC. Reproductive and Developmental Toxicology Branch. ;New Hampshire Univ., Durham. Dept. of Animal and Nutritional Sciences.
Environmental pollutants ;
Male infertility ;
||Some EPA libraries have a fiche copy filed under the call number shown.
It is important that evaluation procedures for chemicals incorporate measures suitable to detect a wide range of potential effects from those chemicals. The reproductive systems are among the most sensitive to toxic insult, so it is important that effective methods be developed and applied for detection of reproductive effects and protection of reproductive capability. As adequate data on the effects of human exposures are seldom available, it is necessary then to use data from other species. Species used most frequently are rodents, rabbits, dogs and subhuman primates. Knowledge gained from research with farm species is being applied in the design of improved protocols to detect health effects. Included are important contributions in developing new evaluation tests, improved experimental design and in furthering understanding of reproductive biology. The paper addresses several testing and risk assessment issues in male reproductive toxicology that form the basis for some of the authors' research.