Record Display for the EPA National Library Catalog


Main Title Effects of Metals on Pulmonary Defense Mechanisms Against Infectious Disease.
Author Graham, J. A. ; Gardner., D. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, N.C. Clinical Studies Div.
Year Published 1977
Report Number EPA/600/J-77/096;
Stock Number PB-278 569
Additional Subjects Meetings ; Toxicity ; Metals ; Immunity ; Lung ; Respiratory diseases ; Infectious diseases ; Immunology ; Toxicology ; Alveolar pulmonis ; Phagocytes ; Bacteria ; Air pollution ; Macrophages ; Immunosuppression ; Air pollution effects(Humans)
Library Call Number Additional Info Location Last
NTIS  PB-278 569 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
The respiratory system under normal conditions has the ability to maintain sterility of the deep lung even when large numbers of microbes are deposited under laboratory conditions. A number of mechanisms have been shown to be responsible for this defense of the lung, namely, mechanical clearance via the mucociliary escalator, biological clearance mediated through the alveolar macrophage (AM), and associated cellular and humoral immunological events. The adverse effects of numerous gaseous pollutants on these pulmonary defense mechanisms against infectious disease have long been recognized. Recently, researchers have begun to investigate the propensity of trace metals for causing similar effects.