Record Display for the EPA National Library Catalog


Main Title Teratogenicity of 5-Azacytidine in the Sprague-Dawley Rat.
Author Rosen, M. B. ; House, H. S. ; Francis, B. M. ; Chernoff., N. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher cFeb 90
Year Published 1990
Report Number EPA/600/J-90/233;
Stock Number PB91-117051
Additional Subjects Genes ; Deoxyribonucleic acids ; Ribonucleic acids ; Fetus ; Body weight ; Congenital abnormalities ; Reprints ; Teratogens ; Azacytidine ; Gestation ; Inbred strains rats ; Ontogeny ; Dose-response relationships
Library Call Number Additional Info Location Last
NTIS  PB91-117051 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
5-azacytidine (5-aza), a chemical which is incorporated into DNA and RNA with consequent alterations in the expression of mammalian genes, was administered to pregnant Sprague-Dawley rats on single days during gestation. Doses of 0.5, 1, and 2 mg/kg were given by intraperitoneal injection on days 9, 10, 11, or 12. Dams were killed on day 20 of gestation and fetuses were examined for both external and skeletal defects. 5-aza affected development on all days tested. The compound was embryolethal, caused reductions in fetal weight, and had profound effects on morphological development. Digit and limb anomalies, exencephaly, micrognathia, gastroschisis, and various rib defects were observed and related to the day of exposure. (Copyright (c) 1990 by Hemisphere Publishing Corporation.)