| Main Title |
Augmentation of Murine Natural Killer Cell Activity by Manganese Chloride. |
| Author |
Rogers, R. ;
Garner, R. ;
Riddle, M. ;
Luebke, R. ;
Smialowicz, R. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA/600/J-83-121; |
| Stock Number |
PB84-123801 |
| Additional Subjects |
Toxicology ;
Cells(Biology) ;
Spleen ;
Mice ;
Activity ;
In vitro analysis ;
In vivo analysis ;
Reprints ;
Manganese chlorides ;
Cytotoxicity
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB84-123801 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
Natural Killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57B1/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels. |
