Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Effects of Cell Source, Mouse Strain, and Immunosuppressive Treatment on Production of Virulent and Attenuated Murine Cytomegalovirus.
Author Selgrade, Maryjane K. ; Nedrud, John G. ; Collier, Albert M. ; Gardner, Donald E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-81-107;
Stock Number PB83-189662
Additional Subjects Viruses ; Mice ; Cells(Biology) ; Production ; Reprints ; Immunosuppression ; Murine cytomegalovirus
Library Call Number Additional Info Location Last
NTIS  PB83-189662 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
Murine cytomegalovirus pools from various in vitro and in vivo sources were compared for virulence in suckling mice in an effort to identify the conditions which were necessary for the production of virulent and attenuated viruses. Virus passaged in tracheal ring and salivary gland organ cultures, where virus is produced primarily by epithelial cells, was even more attenuated than virus passaged in mouse embryo fibroblasts. The attenuation observed after passage in all three of these in vitro systems did not appear to be due to defective interfering particles.