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Main Title Natural Killer Activity in Fischer-344 Rat Lungs as a Method to Assess Pulmonary Immunocompetence: Immunosuppression by Phosgene Inhalation.
Author Burleson, G. R. ; Keyes, L. L. ;
CORP Author Northrop Services, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA-68-02-4450; EPA/600/J-89/267;
Stock Number PB90-198078
Additional Subjects Immunology ; Phosgene ; Respiration ; Lung ; Rats ; Graphs(Charts) ; Tables(Data) ; Reprints ; Natural killer cells ; Immunosuppression ; Immunologic cytotoxicity
Library Call Number Additional Info Location Last
NTIS  PB90-198078 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 25p
Phosgene is a hazardous air toxic and a potential occupational health hazard. Studies were initiated to determine whether exposure to phosgene resulted in local pulmonary or systemic immune dysfunction. The effect of phosgene on lung natural killer (NK) activity was quantified at different times after exposure. Acute phosgene exposure resulted in a suppressed pulmonary NK activity on days 1, 2, and 4 after exposure; however, normal levels of biological activity were observed 7 days after exposure. The suppressed NK activity was not restored after removal of adherent cells. Pulmonary immunotoxicity was also observed after exposure at 0.5 ppm, while no adverse effects were observed at 0.1 ppm phosgene. Systemic immunotoxic effects were observed for NK activity in the spleen, but not in the peripheral blood. The report is the first of a systemic immunotoxic effect after exposure to phosgene. It is thus important in pulmonary immunotoxicology to evaluate systemic immune functions, since secondary effects -- distant to the original interaction -- may occur with potential serious consequences. (Copyright (c) 1989 Marcel Dekker, Inc.)