Record Display for the EPA National Library Catalog


Main Title Allergic response to platinum and palladium complexes : determination of no-effect level /
Author Taubler, James.
CORP Author Saint Vincent Coll., Latrobe, Pa. Dept. of Biology.;Health Effects Research Lab., Research Triangle Park, N.C.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Library ; National Technical Information Service [distributor] ;
Year Published 1977
Report Number EPA 600/1-77/039; EPA-R-803036; PB271659
Stock Number PB-271 659
OCLC Number 39388981
Subjects Platinum--Toxicology ; Palladium--Toxicology ; Allergy--Research
Additional Subjects Platinum ; Palladium ; Allergic diseases ; Immunologic diseases ; Bioassay ; Laboratory animals ; Rabbits ; Guinea pigs ; Mice ; Dosage ; Injections(Medicine) ; Skin(Anatomy) ; Industrial atmospheres ; Catalytic converters ; Air pollution ; Responses ; Contact dermatitis ; Health risks ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-77-039 Headquarters Library/Washington,DC 05/19/2014
EKBD  EPA-600/1-77-039 Research Triangle Park Library/RTP, NC 06/06/2003
ELBD ARCHIVE EPA 600-1-77-039 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD  EPA 600-1-77-039 AWBERC Library/Cincinnati,OH 08/26/2016
NTIS  PB-271 659 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation v, 82 pages ; 28 cm.
Rabbits, guinea pigs and mice were subcutaneously injected with PtSO4 (with and without NH4Cl) and PdSO4 (with and without NH4Cl) in an attempt to sensitize the animals to platinum or palladium. No allergic induction was found. No allergic induction to platinum or palladium was found in rabbits, guinea pigs or mice when these animals were injected intravenously with platinum or palladium. Dermal contact with platinum was also tested on rabbits and guinea pigs but failed to induce an allergic state. Platinum and palladium levels in the sera, urine and spleens of the animals, as monitored by AAS, were not significant. Rabbits, guinea pigs and mice were intravenously or subcutaneously injected with a platinum-egg albumin complex or a palladium-egg albumin complex. Skin tests or footpad tests were performed 10-14 days after the last intravenous or subcutaneous injection. Only guinea pigs injected subcutaneously with palladium-egg albumin complex developed a hypersensitivity of the delayed type. A delayed type allergy was induced in guinea pigs subcutaneously injected with palladium complexed to egg albumin.
"EPA-600/1-77-039." EPA grant no. 803036. EPA project officer: Robert M. Bruce. Includes bibliographical references (page 31).