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RECORD NUMBER: 27 OF 39

OLS Field Name OLS Field Data
Main Title Mapping toxicant-induced nervous system damage with a cupric silver strain : a quantiative analysis of neural degeneration induced by 3,4-methylenedioxymethampethamine /
Author Jensen, Karl F.
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher United States Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1992
Report Number EPA/600/A-92/180
Stock Number PB92-217389
Additional Subjects Toxicology ; Nervous system ; Nerve degeneration ; Dose-response relationships ; Silver staining ; Rats ; Immunohistochemistry ; Dizocilpine maleate ; Fluoxetine ; Copper ; Methylenedioxyamphetamines
Holdings
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Status
NTIS  PB92-217389 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 43 pages ; 28 cm
Abstract
The purpose of structural assessments in neurotoxicology is to provide a convincing picture of the location and extent of damage to the nervous system. Silver stains that selectively reveal neural degeneration hold particular promise in this regard. In the chapter the authors describe results obtained using a cupric silver stain to delineate areas of the brain damaged by administration of 3,4-methylenedioxymethamphetamine (MDMA). MDMA (0,25,50,150, mg/kg as salt) was administered to Long Evans rats 4 times, with a 12 hour interdosing interval. Both the time course and dose dependence of MDMA induced silver staining were evaluated. Silver staining was most prominent in the fronto-parietal neocortex, where the extend of staining was dose-dependent and appeared to be maximal within 18 to 48 following the last dose. The results show that maps of silver staining can demonstrate the dose- and time-dependent of nature of toxicant induced brain damage. With refinement such maps can help identify components of the brain's complex circuitry that are vulnerable to damage by exposure to toxicants.
Notes
Includes bibliographical references. Microfiche.