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RECORD NUMBER: 18 OF 39

Main Title Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury.
Author O'Callaghan, J. P. ; Brinton, R. E. ; McEwen, B. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Rockefeller Univ., New York.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/212;
Stock Number PB91-243030
Additional Subjects Glucocorticoids ; Glial fibrillary acidic protein ; Adrenalectomy ; Stains and staining ; Rats ; Hippocampus ; Cerebral cortex ; Steroids ; Microtubule-associated proteins ; Deoxyribonucleic acids ; Radioimmunoassay ; Trimethyltin ; mRNA ; Northern blotting ; Immunohistochemistry ; Brain injuries ; Reprints ;
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NTIS  PB91-243030 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Abstract
Short (5 days)-to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats. In contrast to CORT, adrenalectomy (ADX) caused elevations (50-125%) in hippocampus and cortex GFAP within 12 days of surgery that persisted for at least 4 months. CORT replacement of ADX rats decreased GFAP amount in hippocampus and cortex. The effects of long-term CORT and ADX on GFAP in hippocampus and cortex were also seen in striatum, midbrain, and cerebellum, findings suggestive of brain-wide adrenal steroid regulation of the astrocyte protein. The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. (Copyright (c) 1991 International Society for Neurochemistry.)