Record Display for the EPA National Library Catalog


Main Title Direct Mutagen Risk Assessment: The Development of Methods to Measure Immunologic and Genetic Responses to Mutagens.
Author Strauss, G. H. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/009;
Stock Number PB85-160455
Additional Subjects Toxicology ; Risk assessments ; Responses ; Mutagenesis ; Immune response ; Genetic response
Library Call Number Additional Info Location Last
NTIS  PB85-160455 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 39p
The review puts forward the concept of Direct Mutagen Risk Assessment through a discussion of the development of methods with which to measure immunologic and genetic responses to mutagens. Mutagenicity risk assessment, in this context, is the study of human somatic cell mutation occurring in vivo and is considered with attention to ideal criteria for detection of mutant cells. Immunotoxicity is addressed particularly in terms of the possible carcinogenic consequences of impaired cutaneous cell-mediated immunity. A section of this review reports the development and the exploitation of the Strauss-Albertini test for enumerating 6-thioquanine-resistant peripheral blood lymphocyte variants. Another section presents results from a system under development, designed to clone and quantitate mutant lymphocytes taken directly from the body. The Clonal Assay of Lymphocyte Mutagenesis (CALM) can confirm that variant cells are mutant and, potentially, could be used comparatively to measure genotoxicity in human or animal lymphocytes after in vivo or in vitro exposures to mutagens.