Record Display for the EPA National Library Catalog


Main Title Immune Function in Adult C57BL/6J Mice Following Exposure to Urethan Pre- or Postnatally.
Author Luebke, R. W. ; Riddle, M. M. ; Rogers, R. R. ; Rowe, D. G. ; Garner, R. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Research Triangle Park, NC.
Year Published 1986
Report Number EPA/600/J-86/174;
Stock Number PB87-115127
Additional Subjects Drugs ; Toxicology ; Neoplasms ; Mice ; Laboratory animals ; Reprints ; Urethan ; Immune response
Library Call Number Additional Info Location Last
NTIS  PB87-115127 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 17p
Administration of urethan (URE or ethyl carbamate) to mice results in the development of a variety of tumors, and, in certain strains of mice, marked supression of the immune response. Perinatal exposure of mice to URE has been found to result in increased tumor induction compared to exposure of adult animals. In the present study, the effects of perinatal exposure to URE on the development of immunocompetence was investigated. Pregnant mice were injected with total doses of either 0.5 or 1.0 mg URE/g of body weight over days 7-16 of gestation or pups of nontreated dams were administered a total dose of 2.0 mg URE/g of body weight over postpartum days 5-14. Postnatal exposure to URE suppressed NK (natural killer) cell activity but left intact other measured parameters of the host defense system. Prenatal exposure, on the other hand, resulted in elevated leukocyte counts and a trend toward increased spleen and thymus size in offspring of treated mothers.