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RECORD NUMBER: 30 OF 31

OLS Field Name OLS Field Data
Main Title Toxic-Induced Hypothermia and Hypometabolism: Do They Increase Uncertainty in the Extrapolation of Toxicological Data from Experimental Animals to Humans.
Author Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1991
Year Published 1991
Report Number EPA/600/J-91/045;
Stock Number PB91-191528
Additional Subjects Toxic substances ; Hypothermia ; Animal disease models ; Rats ; Mice ; Risk assessment ; Body weight ; Toxicity ; Body temperature ; Reprints ; Hypometabolism
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB91-191528 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1991
Collation 7p
Abstract
Commonly used experimental mammals, such as the rat and mouse, exhibit hypothermia and hypometabolism when exposed acutely to many drugs and other chemical substances. This toxic-induced hypothermic/hypometabolic state may be an inherently protective response that can reduce the lethality of a toxic insult. However, as body mass increases, the ability to lower body temperature in response to toxic insult is diminished. Hence, the presence of a protective hypometabolic/hypothermic response in small laboratory mammals and apparent lack thereof in larger species, such as humans, may represent an additional physiological dissimilarity which may underestimate the risk assessment of acute toxicological data.