||Thermoregulatory Effects of Methanol in Fischer and Long Evans Rats.
Mohler, F. S. ;
Gordon, C. J. ;
||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Methyl alcohol ;
Animal behavior ;
Body temperature regulation ;
Inbred strain rats
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The paper will present the results of three studies designed to assess the effects of methanol on body temperature and behavioral thermoregulation in Fischer and Long Evans rats. The first study measured the onset of body temperature changes following methanol exposure. Following gavage of 3 g/kg methanol (20% w/v in saline), brain temperature (Tbr) of Fischer rats decreased 1.5C within 35 min. A similar volume of saline led to transient increases in Tbr. A second study assessed the time course of changes in body temperature by measuring colonic temperature (Tc) hourly following i.p. injection of saline or 1 or 3 g/kg methanol. The highest dosage of methanol caused a significant hypothermia in both Fischer and Long Evans rats. The hypothermia reached its nadir in both strains at 1-2 hours and partially recovered within the 6 hour experiment. The third study measured the effects of methanol on behavioral thermoregulation. Fischer and Long Evans rats were gavaged with saline or 1-3 g/kg methanol and placed in a temperature gradient. After 90 min. in the gradient, rats of both strains which received 2 or 3 g/kg methanol had a significantly lower Tc than control rats.