Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Thermal Influences on Nervous System Function.
Author Janssen, R. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/370;
Stock Number PB93-107159
Additional Subjects Temperature ; Nervous system ; Evoked potentials ; Hyperthermia ; Hypothermia ; Membrane potential ; Peripheral nerves ; Synapses ; Metabolism ; Blood-brain barrier ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-107159 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/08/1993
Collation 17p
The effects of cooling and warming on neural function are reviewed. The literature is presented progressively from the subcellular through the cellular level to the neural systems level. Temporal measures relevant to membrane activity, action potentials, synaptic transmission and evoked potentials are all consistently increased with cooling and decreased by warming. The various measures of amplitude at difference levels, and even within similar preparations, however, are contradictory: some laboratories report increased amplitudes with cooling and others decreased amplitudes under similar conditions. Emphasis is given to identifying-factors which may resolve the differences. These include: (1) the rate of temperature change, (2) sites of cooling, stimulation and recording, (3) stimulus characteristics, and (4) fundamental differences in temperature sensitivities of different neural tissue. Aside from amplitudes, traditional methods and refined methods of predicting neural response to temperature are good.