Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Acute and Delayed Effects of Diisopropyl Fluorophosphate on Body Temperature, Heart Rate and Motor Activity in the Awake, Unrestrained Rat.
Author Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/371;
Stock Number PB93-228971
Additional Subjects Isoflurophate ; Body temperature ; Heart rate ; Motor activity ; Toxicity ; Rats ; Dose-response relationships ; Hypothermia ; Graphs(Charts) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-228971 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 11/22/1993
Collation 14p
Acute exposure to diisopropyl fluorophosphate (DFP) causes irreversible inhibition of acetylcholinesterase activity, leading to various behavioral and autonomic sequelae including hypothermia, reduced motor activity, and other neurological dysfunctions. To characterize the acute response and recovery of autonomic and behavioral processes to DFP exposure, rats of the Long-Evans strain were implanted with radiotransmitters that allowed the monitoring of core temperature, heart rate, and motor activity in unrestrained animals 24 h/d. These parameters were monitored for 96 h following subcutaneous injection of DFP at a dose of 0, 0.1, or 1.0 mg/kg. Rats given 0 and 0.1 mg/kg DFP displayed an increase in core temperature and motor activity during the first 24 h postinjection. Core temperature decreased a maximum of 1.9 C by 5 h after DFP and then started to recover, reaching control levels by 17 h after DFP treatment. Motor activity was also depressed during the first 24-h period in the 1.0 mg/kg group. Heart rate was initially elevated above basal levels in all treatment groups for several hours after treatment, but the 1.0 mg/kg group showed a decrease in heart rate at the time when core temperature began its recovery from hypothermia. Core temperature was the only parameter significantly affected by DFP during the 24-96 h recovery phase.