Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Hypothermic Effects of a Homologous Series of Short-Chain Alcohols in Rats.
Author Mohler, F. S. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/044;
Stock Number PB91-191510
Additional Subjects Toxicity ; Body temperature regulation ; Hypothermia ; Propanol ; Butanol ; Rats ; Dose-response relationships ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-191510 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 09/04/1991
Collation 13p
The purpose of the study was to assess the toxicity of various short-chain alcohols using the thermoregulatory system of the rat as an endpoint. Male Fischer rats developed significant hypothermia following acute administration (i.p.) of methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, or 2-butanol. The hypothermic responses to the six alcohols all showed similar bimodal responses characterized by a threshold dose below which no change in body temperature occurred, and a suprathreshold regression with increasing dose causing greater hypothermia. Relative efficacy of the alcohols was compared using both the threshold dose to cause hypothermia and the dose which would cause body temperature to decrease by 1 C. Both measures gave the progression of toxicity from least to most potent of: methanol