||Carboxyhemoglobin Formation Due to Carbon Monoxide Exposure in Rats.
Benignus, V. A. ;
Annau, Z. ;
||Health Effects Research Lab., Research Triangle Park, NC. Human Studies Div. ;North Carolina Univ. at Chapel Hill. Dept. of Psychology. ;Department of State, Washington, DC. Bureau of Oceans and International Environmental and Scientific Affairs.
Carbon monoxide ;
Air pollution effects(Animals) ;
Acute exposure ;
Blood chemical analysis ;
Biological effects ;
Differential equations ;
Statistical analysis ;
CFKE(Coburn-Forster-Kane equation) ;
Coburn-Forster-Kane equation ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The Coburn-Forster-Kane equation (CFKE) is a well tested model for prediction of COHb formation due to carbon monoxide (CO) exposure in humans. There have been few and relatively poorly tested attempts to implement a CFKE for rats. Such an implementation is of interest because many experiments on the effects of CO in rats were done without measuring COHb. To extrapolate from rats to humans requires a rat version of the CFKE. A CFKE was implemented for rats by using parameters found in the literature and estimating them from the data. It was deduced from the blood-gas data that rats hyperventilate slightly as COHb increases. The hyperventilation required an iterative solution to the CFKE. The iterative CFKE predictions were found to differ statistically from observations, but in explainable ways and/or in small amounts.