Record Display for the EPA National Library Catalog

RECORD NUMBER: 12 OF 22

Main Title Evidence for Effects of Chronic Lead Exposure on Blood Pressure in Experimental Animals: An Overview.
Author Victery, W. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
Year Published 1988
Report Number EPA/600/D-88/018;
Stock Number PB88-170097
Additional Subjects Lead(Metal) ; Blood pressure ; Reviews ; Exposure ; Hypertension ; Models ; Toxicology ; Laboratory animals ;
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB88-170097 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Abstract
Information obtained in a number of experimental studies conducted over the last forty years on the effects of lead on blood pressure is reviewed. Differences in animal species, age at beginning of exposure, level of lead exposure, indices of lead burden, and blood pressure effects of each study are reported. In several of the high-dose experiments, hypertension was observed, but nephrotoxicity of lead may have contributed to its development. Moreover, in other high-dose experiments, no hypertension was observed and in at least one, the evidence suggested that lead could reduce an elevated blood pressure. In contrast, the lower-dose experiments consistently demonstrated a hypertensive effect. Overall, the data suggest a biphasic dose response.