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RECORD NUMBER: 42 OF 60

OLS Field Name OLS Field Data
Main Title Initial Submission: TKA 40207, Contact Hypersensitivity in Albino Guinea Pigs Maximization Test, with Cover Letter dated 11/03/99 (Sanitized).
CORP Author CIBA Specialty Chemical Corporation ;RCC, Ltd.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 4 Nov 1999
Year Published 1999
Report Number 8EHQ-1199-14582S;
Stock Number OTS-0559829
Additional Subjects Toxicity ; Guinea pigs ; Females ; Laboratory animals ; Intradermal induction ; Dosage ; Skin reactions ; Assessments ; Contact hypersensitivity ; Cutaneous allergenic potentials ; TKA 40207 ; Maximization-Test
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Status
NTIS  OTS-0559829 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 10/08/2007
Collation 57p
Abstract
In order to assess the cutaneous allergenic potential of TKA 40207 the Maximization-Test was performed in 15 (10 test and 5 control) female albino guinea pigs, in accordance with OECD Guideline No. 406 and the Directive 96/54/EEC, B.6. The intradermal induction of sensitization in the test group was performed with a 5 % dilution of the test article in acetone/olive oil (l:1, v/v) and in an emulsion of Freund's Complete Adjuvant (FCA) / physiological saline. The epidermal induction of sensitization was conducted under occlusion with the test article at 25 % in acetone/olive oil (1:1, v/v) one week after the intradermal induction. The animals of the control group were intradermally induced with acetone/olive oil (l:1, v/v) and FCA/physiological saline and epidermally induced with acetone/olive oil (1:1, v/v) under occlusion. Two weeks after epidermal induction the control and test animals were challenged by epidermal application of the test article at 5 % in acetone/olive oil (l:1, v/v) and acetone/olive oil (1:1, v/v) alone under occlusive dressing. Cutaneous reactions were evaluated at 24 and 48 hours after removal of the dressing.