Record Display for the EPA National Library Catalog


Main Title Hydroquinone: A Developmental Toxicity Study in Rats with Cover Letter and EPA Acknowledgement Letter.
CORP Author Eastman Kodak Co., Rochester, NY. Health and Environment Labs.;Chemical Manufacturers Association, Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher Sep 1985
Year Published 1985
Report Number FYI-AX-1285-0468;
Stock Number OTS-0000468-0
Additional Subjects Rats ; Hydroquinone ; Toxicity ; Body weight ; Feed consumption ; Malformations ; Toxicity studies
Library Call Number Additional Info Location Last
NTIS  OTS-0000468-0 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 94p
The objective of this study was to determine the development toxicity potential of hydroquinone in the rat. Pregnant Crl: COBS 'CD' (SD) BR rats were given 0, 30, 100 or 300 mg/kg of hydroquinone by gavage on the 6th through the 15th days of gestation and fetuses were examined near term. Maternal toxicity was seen as a slight but statistically significant reduction in body weight gain and feed consumption during the treatment period in the dams given 300 mg/kg hydroquinone. A few spontaneous malformations were seen, but no compound-related teratogenic effects were found. Minor soft tissues and skeletal changes, variations commonly found in developmental toxicity studies, did not occur at a significantly higher incidence in the treated groups than in the control group. Reproductive indices of the hydroquinone dams were comparable to the controls. A reduction in mean fetal body weight seen at the high dose level (300 mg/kg) correlated with the reduced body weight seen in the dams at this dose level. In conclusion, doses as high as 300 mg/kg hydroquinone did not produce teratogenic effects, other embryotoxicity, or fetotoxicity in the rat.