Record Display for the EPA National Library Catalog


Main Title Recent Advances in the Development and Use of Physiologically Based Toxicokinetic Models for Fish.
Author Nichels, J. W. ;
CORP Author National Health and Environmental Effects Research Lab., Duluth, MN. Mid-Continent Ecology Div. (Duluth) Library.
Publisher Aug 1998
Year Published 1998
Report Number EPA/600/A-99/089;
Stock Number PB2000-102973
Additional Subjects Fishes ; Toxicology ; Water pollution effects(Animals) ; Chemical kinetics ; Models ; Organic chemicals ; Absorption ; Elimination ; Hydrophobicity ; Metabolism ; Toxicokinetics
Library Call Number Additional Info Location Last
NTIS  PB2000-102973 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Existing physiologically based toxicokinetic (PBTK) models for fish accurately predict the uptake and disposition of waterborne organic chemicals of low to intermediate hydrophobicity. These models have been used to evaluate factors that control chemical kinetics in fish and to extrapolate data among fish species. The utility of these models is limited, however, by a lack of understanding of the factors that control chemical uptake from dietary sources and an inability to measure, describe, and predict metabolic biotransformation. In this chapter, critical questions related to dietary uptake and metabolic biotransformation are identified and discussed. Research with fish that addresses some of these questions is presented. Guidance is also provided from modeling efforts with mammalian species. It is recommended that future research be directed towards developing a relatively simple gut sub-model description. In vitro methods for characterizing chemical biotransformation must be complemented by new techniques for measuring metabolism in the intact animal.