Hydromodification activities are driven by human population growth and resource extraction and consumption including urbanization, agriculture, forestry, mining, water withdrawal, climate change, and flow regulation by dams and impoundments. These anthropogenic activities alter natural flow regimes and lead to reduced downstream water quantity and degraded water quality. Recently, USEPA and states recognized hydromodification as a stressor and a leading source of water quality impairment in streams and rivers. Hydromodification-induced stressors include chemical pollutants, pathogens, nutrients, suspended solids, and flow and habitat alteration.