Record Display for the EPA National Library Catalog

RECORD NUMBER: 16 OF 25

Main Title Selection of a Model System to Determine the Effects of Energy Production by-Products on the Immune System. Progress Report, January 1--September 30, 1976.
Author Smith., D. M. ;
CORP Author Los Alamos Scientific Lab., N.Mex.;Energy Research and Development Administration.
Year Published 1976
Report Number W-7405-ENG-36 ;EPA-IAG-D5-E6;
Stock Number LA-6603-PR
Additional Subjects Aerosols ; Oil shale processing plants ; Biological effects ; Carcinogens ; Hamsters ; Health hazards ; Immunity ; Oil shales ; Polycyclic aromatic hydrocarbons ; Research programs ; ERDA/560301 ; ERDA/041000 ; Immunology ; Experimental data ; Animal models ; Toxicology
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  LA-6603-PR Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract
Immune system function for rats and hamsters is described, and normal values are given for T-cell exp 3 H-uridine uptake, phytohemagglutinin and concanavalin A-induced lymphocyte mutagenesis in vitro with and without 2-mercaptoethanol addition to the cultures, histologic evaluation of phytohemagglutinin skin testing, T-lymphocyte-dependent cytotoxicity, B-lymphocyte erythrocyte-antibody-complement formation, and B-lymphocyte globulin production mediated hemolytic plaque production. Also included are erythrocyte-antibody-complement rosette values for blood lymphocytes from thymectomized hamsters. A pilot study is described in which Syrian hamsters were exposed to aerosolized spent oil shale (33 mg/l respirable mass) 4.5 h a day, 4 days a wk, for 6 wk. Total white blood cell counts, differential white blood cell counts, red blood cell counts, hematocrits, and hemoglobin determinations in experimental animals did not differ significantly from those of control animals. (ERA citation 02:027572)