Record Display for the EPA National Library Catalog


Main Title Impairment of Calcium Homeostasis by Hexachlorobenzene (HCB) Exposure in Fischer 344 Rats (Journal Version).
Author Andrews, J. E. ; Courtney, K. D. ; Donaldson, W. E. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina State Univ. at Raleigh.
Publisher c1988
Year Published 1988
Report Number EPA/600/J-88/061;
Stock Number PB89-110332
Additional Subjects Calcium metabolism disorders ; Toxicity ; Calcitriol ; Homeostasis ; Cholesterol ; Liver ; Chlorohydrocarbons ; Laboratory animals ; Kidney ; Parathyroid hormone ; Reprints ; Hexachlorobenzene ; Alanine aminotransferase ; Benzene/hexachloro ; Vitamin D deficiency ; Body weight
Library Call Number Additional Info Location Last
NTIS  PB89-110332 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Human exposure to hexachlorobenzene (HCB) has resulted in demineralization of bone with osteoporosis resulting. Experiments were undertaken to investigate the effects of HCB on the homeostatic mechanism of calcium metabolism. Fischer 344 rats were dosed with 0, 0.1, 1.0, 10.0 or 25.0 mg HCB/kg body weight 5 days/wk for 5 wks while being fed normal rat diet or vitamin D3 deficient diet. Rats receiving the normal diet had a dose-related decrease in body weight gain and increased liver weight when compared to their controls. Serum cholesterol, alanine aminotransferase (ALT), 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D) and parathyroid hormone (PTH) were significantly elevated when compared to control values. In the vitamin D3 deficient diet group, there was a dose related increase in liver weight, liver-to-body-weight ratio and kidney-to-body-weight ratio. Serum cholesterol and 1,25-(OH)2D were significantly elevated. The data indicate that HCB does affect calcium metabolism by altering the concentrations of two primary controlling factors in calcium homeostasis. (Copyright (c) 1988 by Hemisphere Publishing Corporation.)