Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 29

OLS Field Name OLS Field Data
Main Title Effect of Hexamethyldisiloxane on the Incidence of Chromosome Breaks and Aberrations in Rat Bone Marrow Cells.
CORP Author Industrial Health Foundation, Inc., Pittsburgh, PA.; Bioassay Systems Corp., Woburn, MA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001601
Stock Number OTS0572636
Additional Subjects Toxicology ; Health effects ; Hexamethldisiloxane ; Toxicity ; Genotoxicity ; Chromosomal effects ; Mammals ; Rats ; Parenteral ; Intraperitoneal ; CAS No 107-46-0 ; Hexamethyldisiloxane (CAS No 107-46-0) ; Toxic substances ; Laboratory animals
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NTIS  OTS0572636 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 43p
Abstract
Hexamethyldisiloxane was tested for its ability to cause chromosomal damage in bone marrow cells in rats. Sprague-Dawley rats were injected intraperitoneally with 1030, 515 and 255 mg/kg of hexamethyldisiloxane. Doses higher than 1030 were not tested since some lethality was observed at 1825 mg/kg. Animals were sacrificed at 6, 24, or 48 hours after injection; cells were removed, processed and examined for chromosomal breaks and/or aberrations. There was no evidence in this study that hexamethyldisiloxane caused chromosomal damage.