Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Two-week Repeated Dose Inhalation Toxicity Study of Hexamethyldisiloxane in Albino Rats with Cover Letter dated 04/20/94.
CORP Author Dow Corning Corp., Midland, MI.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 8EHQ-86940001809
Stock Number OTS0572321
Additional Subjects Toxicology ; Health effects ; Hexamethyldisiloxane ; Toxicity ; Subchronic toxicity ; Mammals ; Rats ; Inhalation ; CAS No 107-46-0 ; Toxic substances ; Laboratory animals
Library Call Number Additional Info Location Last
NTIS  OTS0572321 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 41p
A study was conducted to evaluate the potential toxicity of hexamethyldisiloxane following inhalation exposure. Three groups of 5 male and 5 female Sprague-Dawley rats were exposed via inhalation to concentrations of 0, 499 ppm, or 1004 ppm hexamethyldisiloxane, for 6 hours per day, 5 days per week, for 2 weeks. The animals were observed daily for mortality or treatment-related toxicity, including respiratory, dermal, behavioral, nasal, and ocular effects and/or body weight changes. Following the final exposure, animals were sacrificed and gross pathological exams, including weighing of organs, as well as histopathological exams were conducted. All animals survived to terminal sacrifice. There were no significant differences in mean body weight in treated animals compared to controls. In the males only, there was a dose-related trend toward increased mean kidney weight. When expressed as kidney to body weight and kidney to brain weight ratio statistically significant increases were observed in the 1000 ppm males. These organ weight changes appeared to correspond with an increased severity of hyaline droplets in the proximal convoluted tubule, ie. hydrocarbon nephropathy, of the treated male rats. Hydrocarbon nephropathy is unique to male rats and is not observed in humans. No other significant toxicological effects were observed.