Record Display for the EPA National Library Catalog

RECORD NUMBER: 19 OF 29

OLS Field Name OLS Field Data
Main Title Mutagenicity Evaluation of Hexamethyldisiloxane. Final Report.
CORP Author Litton Bionetics, Inc., Bethesda, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1994
Report Number 86940001687
Stock Number OTS0572722
Additional Subjects Toxicology ; Health effects ; Hexamethyldisiloxane ; Genotoxicity ; Gene Mutations ; Mammals ; Mice ; In Vitro ; Toxic substances ; Laboratory animals ; CAS No 107-46-0
Holdings
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Status
NTIS  OTS0572722 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 8p
Abstract
Hexamethyldisiloxane did not produce responses in the L5178Y mouse lymphoma cells which indicated consistent genetic activity. Several scattered increases appeared to be the result of spurious fluctuations and cytotoxicity. The only evidence of a genotoxic response was the induction of chromosome aberrations under non-activation test conditions. These data can be considered evidence for weak clastogenic activity.