||Mutagenicity Evaluation of Hexamethyldisiloxane. Final Report.
||Litton Bionetics, Inc., Bethesda, MD.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Gene Mutations ;
In Vitro ;
Toxic substances ;
Laboratory animals ;
CAS No 107-46-0
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Hexamethyldisiloxane did not produce responses in the L5178Y mouse lymphoma cells which indicated consistent genetic activity. Several scattered increases appeared to be the result of spurious fluctuations and cytotoxicity. The only evidence of a genotoxic response was the induction of chromosome aberrations under non-activation test conditions. These data can be considered evidence for weak clastogenic activity.