An acute dermal irritation study was conducted to assess the skin irritation potential of methyl disiloxane in male New Zealand white rabbits. The test material (0.5 ml) was applied uniformly to two intact, shaved test sites on the dorsal side of 12 male rabbits. The test site was then covered with a semiocculsive covering. Adjacent areas of untreated skin served as the control. The test animals were observed for signs of toxicity, mortality, and general activity. The application sites from groups of 4 animals were examined at 1, 2, 4, 8, 16, and 24 hours post-exposure. Skin irritation scores for erythema, edema, and other evidence of irritation were noted for all animals. No skin irritation was observed in any of the animals at any of the time points examined. In addition, no obvious effects on body weight gain, food consumption, survival, or animal behavior were observed. This assessment indicates methyl disiloxane did not produce dermal irritation or other observable signs of toxicity.