| Main Title |
Dose-Dependency of 2-Acetylaminofluorene Binding to Liver DNA and Hemoglobin in Mice and Rats. |
| Author |
Pereira, Michael A. ;
Lin, Luan-Ho C. ;
Chang, Lina W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1981 |
| Report Number |
EPA-600/J-81-141; |
| Stock Number |
PB82-247503 |
| Additional Subjects |
Carcinogens ;
Liver ;
Dosage ;
Mice ;
Rats ;
Laboratory animals ;
Deoxyribonucleic acid ;
Hemoglobins ;
Ingestion(Biology) ;
Binding ;
Nitrogen organic compounds ;
Reprints ;
Fluorene/acetyl-amino
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-247503 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The carcinogenic activity of 2-acetylaminofluorene (2-AAF) in mice and rats has been accurately described so that it is a suitable archetypical chemical for investigations of parameters of cross-species variation. The results of the study supported a pharmacokinetic model that related the metabolism of 2-AAF to reactive metabolites to the binding of the metabolite to DNA and hemoglobin. The results do not support a relationship of macromolecular binding to carcinogenic potency. |
