Record Display for the EPA National Library Catalog


Main Title Oxidation of Cardiac Myoglobin In vivo by Sodium Nitrite or Hydroxylamine.
Author Nichols, J. W. ; Weber, L. J. ;
CORP Author Environmental Research Lab.-Duluth, MN. ;Oregon State Univ., Newport. Hatfield Marine Science Center.;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/288; NIEHS-ES-07060;
Stock Number PB90-196551
Additional Subjects Sodium nitrates ; Hydroxylamine ; Myoglobin ; In vivo analysis ; Oxidation ; Hemoglobin ; Methemoglobins ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB90-196551 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
A non-vascularized fish heart model was used to assess the oxidation of cardiac myoglobin in vivo by compounds known to cause methemoglobinemia. Buffalo sculpin (Enophrys bison) were cannulated from the afferent branchial artery to permit repeated blood sampling and injected intraperitoneally with sodium nitrite, hydroxylamine or aniline. Methemoglobin was formed by sublethal levels of sodium nitrite or hydroxylamine. For hydroxylamine, the time to peak effect was less than 1 h. For sodium nitrite, the onset was less rapid and the effect more prolonged. Aniline had no effect on hemoglobin at any concentration tested. The study suggests the possibility that cardiac myoglobin is oxidized in occupational or other exposures to sodium nitrite, hydroxylamine and related compounds. (Copyright (c) 1989 Springer-Verlag.)