Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Modulating Effect of Body Temperature on the Toxic Response Produced by the Pesticide Chlordimeform in Rats.
Author Watkinson, W. P. ; Highfill, J. W. ; Gordon, C. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/369;
Stock Number PB90-215906
Additional Subjects Body temperature ; Pesticides ; Toxicology ; Electrocardiography ; Rats ; Statistical analysis ; Heart rate ; Graphs(Charts) ; Lethal dosage ; Reprints ; Chlordimeform
Library Call Number Additional Info Location Last
NTIS  PB90-215906 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 20p
To investigate the role of body core temperature (Tco) on chlordimeform (CDM) toxicity, experiments were conducted over a range of Tcos. Adult rats were anesthetized with sodium pentobarbital and randomly assigned to one of six equal groups. Groups were paired and Tco was maintained in the rats in each of the respective group pairs at one of three levels. Rats in one group at each temperature level were injected intraperitoneally with 60 mg/kg of CDM. Animals in the corresponding temperature-matched groups received volume-matched injections of normal saline vehicle and served as time-paired controls. The electrocardiogram and heart rate (HR) were monitored throughout the experimental procedure. There was a significant decrease in HR in all CDM-treated groups when compared to the control group animals. The magnitude of the observed cardiac effect was attenuated in the T35 group when compared to that of the other treated groups. Similarly, lethality rates (no. deaths/no. total) for the T37, T35, and T33 groups were 2/5, 0/5, and 3/5, respectively; there were no deaths among the control group animals. From these and previous data from this laboratory, the authors conclude there may be a beneficial effect of hypothermia in rats exposed to toxic agents which is maximal around 35 C.